ea0009oc11 | Oral Communication 2: Reproduction and growth | BES2005
Arlt W
, Hammer F
, Filko D
, Chalder S
, Hughes B
, Sanning P
, Schofl C
, Stewart P
Dehydroepiandrosterone (DHEA) is the crucial androgen precursor and hyperandrogenaemia is a major feature in Polycystic Ovary Syndrome (PCOS). DHEA sulfate (DHEAS) is generated from DHEA by DHEA sulfotransferase (SULT2A1) activity. The conversion of DHEAS to DHEA by steroid sulfatase has been reported to be of minor significance in human adults and only desulfated DHEA can be converted toward androgens. Therefore, SULT2A1 activity represents the rate-limiting step regulating t...